The rise of synthetic biology and its various offshoot applications in climate tech, biotech, medtech, foodtech and allied technologies such as DNA data storage presents unprecedented opportunities for innovation and societal benefits, while also creating new challenges in biosecurity. This session will explore strategies to secure the synbio supply chain, opportunities and challenges in scalable containment technologies, traceability systems such as genomic barcoding, deployment of AI solutions for biosecurity, and frameworks for managing the intellectual property (IP) rights of engineered biological assets in a rapidly complexifying supply chain. Our expert panel will discuss the role of emerging technologies in enhancing supply chain transparency, safeguarding against misuse, and ensuring compliance with evolving regulatory landscapes. Join us to gain valuable perspectives on how collaborative public-private efforts, innovative digital and molecular tools, and adaptable regulatory practices can maintain security, foster ethical growth, and protect public trust across the engineering biology ecosystem.