Jason Chin
Jason Chin is the Founder Director and CSO of Constructive Biology. Jason Chin is renowned for pioneering whole-genome writing, deep genetic code rewiring, and genetic code expansion. He is the inventor of a suite of transformative technologies in these fields and has authored over 150 publications, including 15 in Nature and Science.
Beyond his role at Constructive Biology, Jason is a Founding Director of the Generative Biology Institute (GBI) at the Ellison Institute of Technology and serves as a Non-Executive Director at the UK Government’s Department for Science, Innovation, and Technology.
Prior to launching GBI, Jason was a Programme Leader at the Medical Research Council Laboratory of Molecular Biology (MRC-LMB), where he also led the Centre for Chemical & Synthetic Biology (CCSB) and co-headed the Division of Protein and Nucleic Acid Chemistry. He was a Professor of Chemistry and Chemical Biology at the University of Cambridge, a founding Associate Faculty Member in Synthetic Genomics at the Wellcome Sanger Institute, and a Fellow and Director of Studies in Biochemistry at Trinity College, Cambridge.
Jason’s groundbreaking contributions to science have been widely recognized. He received the Francis Crick Prize (Royal Society, 2009), the Corday-Morgan Prize (Royal Society of Chemistry, 2010), and the EMBO Gold Medal (2010). He was the inaugural recipient of the Louis-Jeantet Young Investigator Career Award (2011) and was awarded the Sackler International Prize in the Physical Sciences (2019).
Jason is a Fellow of The Royal Society, the Academy of Medical Sciences, and the European Molecular Biology Organization (EMBO). His impact on biotechnology and synthetic genomics has earned him a place in the European Patent Office Inventor Hall of Fame.
Constructive Bio
Rewriting Life’s Code to Create New Polymers, Materials, and Medicines
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In terrestrial life, DNA is copied to messenger RNA, and the 64 triplet codons in messenger RNAs are decoded – in the process of translation – to synthesize proteins. Cellular protein translation provides the ultimate paradigm for the synthesis of long polymers of defined sequence and composition but is commonly limited to polymerizing the 20 canonical amino acids. I will describe our progress towards the encoded synthesis of non-canonical biopolymers. These advances may form a basis for new classes of genetically encoded polymeric materials and medicines. To realize our goals, we are re-imagining some of the most conserved features of the cell; we have created new ribosomes, new aminoacyl-tRNA synthetase/tRNA pairs, and organisms with entirely synthetic genomes in which we have re-written the genetic code.
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