Kosuke Fujishima
Kosuke Fujishima is an Associate Professor at the Earth-Life Science Institute (ELSI) at Institute of Science Tokyo. His research focuses on the origin of life and cell-free system, particularly the transition from prebiotic chemistry to biological systems. With a background in molecular evolution and synthetic biology, he investigates the interplay between RNA and peptides, testing the "peptide-RNA coevolution hypothesis" using in vitro synthesized de novo peptides and proteins. Dr. Fujishiima has pioneered work on the role of ancient proteins in metabolism and genetic systems, contributing to the emerging field of Synthetic Astrobiology. His recent research includes the development of a cell-free Fe-S protein synthesis system for studying oxygen-sensitive metalloenzymes and the integration of amino acid biosynthesis into a mixotrophic PURE system, advancing efforts toward a self-sustaining artificial cell. His work has been published in leading journals, including ACS Catalysis. Prior to his current role, he held research positions at NASA Ames Research Center in Rothschild lab, where he worked extensively on utilizing synthetic biology for future Mars exploration and life detection missions.
Institute of Science Tokyo
PURE System: A Quarter-Century of Innovation and Future of Cell-Free System in Synthetic Biology
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The PURE (Protein synthesis Using Recombinant Elements) system is a reconstituted cell-free protein synthesis system invented by Prof. Ueda in 2001. This session will reflect on 25 years of this groundbreaking platform, trace its evolution and explore its core principles and advantages in today's synthetic biology landscape. Learn how this critical system works synergistically with other technologies including microfluidics, high-throughput screening platforms, in vitro display, AI/ML-approach to advance applications in basic research, protein engineering, and biologics R&D. Join the original developers of this technology to explore future directions and potential novel uses of PURE system technology to revolutionize fields such as personalized medicine, biomanufacturing, and artificial cells.
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Until Friday April 18th
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