This session will examine the frontiers of genomic sequencing and synthesis, providing a critical assessment of the present capabilities and charting likely trajectories for future progress. Participants will highlight the latest advances in instrumentation, informatics, and automation that are pushing beyond conventional limits, while also considering emerging technologies poised to reshape the landscape of DNA reading and writing. By focusing on accuracy, throughput, and scalability, this discussion will illuminate the fundamental shifts now taking place and the new horizons they open for biological research and innovation.